Depregon’s formula is based on Licorice Root, an herb most commonly known for its use in remedies for sore throat and lung ailments, gastric and mouth ulcers, and as an overall “immunity booster”.

Licorice Root, Depregon’s “star” ingredient, is offered in the formula as “an alternative for those individuals who can not tolerate St. John's Wort,” according to the product’s manufacturer. Indeed, St. John’s Wort, an herb touted as having antidepressant properties, can cause unpleasant side effects (like headaches, stomach aches and worse) in some users, and can also interfere with some prescription medications.

Though some research on menopausal women has suggested that Licorice Root may offer some mood-elevating benefits, the bulk of the evidence so far remains anecdotal. The product’s website doesn’t cite any studies or customer reviews. Several clinical trials have, however, found that the herb may hold some promise in easing Hepatitis C complications in some patients.

Depregon also contains nutrients, like Folate and B Vitamins, which play a role in the production of the neurotransmitter Serotonin. Low levels of Serotonin are believed to be associated with depression, anxiety and other disorders.

Though Depregon may well address some symptoms of depression, many more studies on the safety and effectiveness of Licorice Root for depression and mood disorders need to be conducted before we can feel comfortable recommending its use. Because potential side effects and long-term use have yet to be fully studied or understood, many healthcare professionals caution against using it for periods longer than 4 weeks. This may be of particular concern to former users of St. John’s Wort who are considering the use of Depregon as a “safe” alternative.

People in the market for a natural, nonprescription supplement to safely ease anxiety and stabilize emotions and mood swings might be better advised to consider a formula with the natural mineral form of Lithium. When combined with Oronate, a carrier that delivers the mineral precisely where needed, benefits are optimized, so only minute amounts are required for marked improvements in mood and anxiety—eliminating worries about toxicity or side effects.

• Natural product
• Contains some vitamins and basic nutrients
• May provide an alternative to St. Johns Wort

• May cause harmful side effects, for some when taken with certain prescription medications, during pregnancy, or by people with heart disease or high blood pressure
• Free trial samples are not offered
• Does not contain cutting-edge mood-balancing agents like the natural mineral lithium
• Website does not cite studies or customer testimonials

There are many valid reasons for choosing a natural, nonprescription supplement to help calm anxiety and achieve peace of mind. Safety, effectiveness and freedom from unwanted side effects are usually top on the list.

Rather than take a chance with formulas that may not have been fully tested and explored, consumers may want to opt for a product that features the mineral form of Lithium—a substance that occurs naturally in the human body. Studies suggest that gently boosting Lithium levels can have calming, stabilizing effects. And try before you buy: We strongly urge seeking out manufacturers who offer free trial samples whenever possible.